|
KMID : 1094020230400040298
|
|
Journal of Veterinary Clinics
2023 Volume.40 No. 4 p.298 ~ p.302
|
|
|
Non-B, Non-T Acute Lymphoblastic Leukemia in a Cat
|
|
Cha Su-Min
Kim Hyun-Woo
Bae Hyeon-A
Kang Min-Jeong
Jung Ran-Kyung
Kim Min-Ji
Yu Do-Hyeon
|
|
|
Abstract
|
|
|
|
A 7-year-old neutered male, domestic shorthair cat presented anorexia and lethargy. The complete blood cell count revealed severe non-regenerative anemia, lymphocytic leukocytosis, neutropenia, and thrombocytopenia. On the peripheral blood smear examination, medium to large lymphoblastic cells with moderate amounts of basophilic cytoplasm were observed in up to 70% of peripheral leukocytes. Feline leukemia and immunodeficiency viruses were not detected using a commercial diagnostic kit. While splenomegaly and blunt margins of the caudoventral liver were observed in abdominal radiography, changes in the intra-abdominal lymph nodes were not remarkable. Ultimately, flow cytometric immunophenotyping from the peripheral blood revealed a negative for B-cell markers (CD21-/CD79a-) and T-cell markers (CD3-/CD4-/CD5-/CD8-). Based on the hematological examination and the immunophenotyping assay, the cat was diagnosed with non-B, non-T acute lymphoblastic leukemia. Here, we report a rare case of non-B, non-T acute lymphoblastic leukemia to raise awareness and provide information on clinical symptoms and laboratory test and immunophenotyping analysis results.
|
|
|
KEYWORD
|
|
|
acute lymphoblastic leukemia, flow cytometry, PARR assay, non-B, non-T lymphoid leukemia, cat
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|